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BRCA1和BRCA2基因突变相关性乳腺癌的普查和预防

胡震, 沈镇宙, 邵志敏

胡震, 沈镇宙, 邵志敏. BRCA1和BRCA2基因突变相关性乳腺癌的普查和预防[J]. 实用临床医药杂志, 2003, (2): 121-123. DOI: 10.3969/j.issn.1672-2353.2003.02.007
引用本文: 胡震, 沈镇宙, 邵志敏. BRCA1和BRCA2基因突变相关性乳腺癌的普查和预防[J]. 实用临床医药杂志, 2003, (2): 121-123. DOI: 10.3969/j.issn.1672-2353.2003.02.007
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The interrelationship of BRCA1 and BRCA2 gene mutation in the survey and prevention of breast cancers[J]. Journal of Clinical Medicine in Practice, 2003, (2): 121-123. DOI: 10.3969/j.issn.1672-2353.2003.02.007
Citation: The interrelationship of BRCA1 and BRCA2 gene mutation in the survey and prevention of breast cancers[J]. Journal of Clinical Medicine in Practice, 2003, (2): 121-123. DOI: 10.3969/j.issn.1672-2353.2003.02.007
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BRCA1和BRCA2基因突变相关性乳腺癌的普查和预防

  • 复旦大学乳腺癌研究所、复旦大学附属肿瘤医院乳腺外科,上海,200032

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  • 中图分类号: R737.9

The interrelationship of BRCA1 and BRCA2 gene mutation in the survey and prevention of breast cancers

摘要

    摘要
  • 摘要: BRCA1和ARCA2基因是抑癌基因,它们主要参与DNA损伤的修复和转录的调控.这两个基因的结构和功能异常与乳腺癌的发病密切相关.BRCA1、BRCA2突变相关性乳腺癌具有发病早、双侧性等特点.基因突变携带者的乳腺癌危险度远远高于一般……
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    • 参考文献(8)
  • Phillips K A. Immunophenotypic and pathologic differences between BRCA1 and BRCA2 hereditary breast cancers [J]. Journal of Clinical Oncology, 2000.107s.
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    Meijers-Heijboer H, van Geel E, van Putten W L. Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation [J]. New England Journal of Medicine, 2001.159.doi: 10.1056/NEJM200107193450301.
    Rebbeck T R, Levin A M, Eisen A. Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers [J]. Journal of THE NATIONAL CANCER INSTITUTE, 1999, (17):1475.doi: 10.1093/jnci/91.17.1475.
    Narod S A, Brunet J S, Ghadirtan P. Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study [J]. LANCET, 2000, (9245):1876.
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  • 发布日期:  2004-07-30

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